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What is minoxidil, the anti-balding hair growth treatment? Here’s what the science says

<p><a href="https://theconversation.com/profiles/jacinta-l-johnson-1441348">Jacinta L. Johnson</a>, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em> and <a href="https://theconversation.com/profiles/kirsten-staff-1494356">Kirsten Staff</a>, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em></p> <p>Hair loss (also known as alopecia) often affects the scalp but can occur anywhere on the body. It’s very common and usually nothing to worry about; about <a href="https://www.sciencedirect.com/science/article/pii/S0022202X15525840">half of Australian men</a> show signs of visible baldness at age 50 and <a href="https://www.sciencedirect.com/science/article/pii/S0022202X15525840">over a quarter of Australian women</a> report hair thinning by the same age. It’s often genetic.</p> <p>But if you’ve noticed hair loss and are worried by it, see a GP or dermatologist for a diagnosis before trying any treatments. Products claiming to reverse hair loss are everywhere, but few have been scientifically tested for how well they work.</p> <p>One group of products that have actually been scientifically tested, however, are known as topical minoxidil products. These include products such as Regaine®.</p> <p>So, do they work? Here’s what the research evidence says, what you can realistically expect and what you need to know if you’re considering this treatment.</p> <h2>What is minoxidil – and does it work?</h2> <p>Topical minoxidil usually comes as a kind of foam or serum you apply to your scalp.</p> <p>It’s been approved by the <a href="https://www.tga.gov.au/">Therapeutic Goods Administration</a>, Australia’s regulatory authority for therapeutic goods, for the treatment of hereditary hair loss in males and females. Minoxidil is also available in tablet form, but this isn’t currently approved for hair loss (more on that later).</p> <p>So, is topical minoxidil effective? In short – yes, but the results vary widely from person to person, and it needs to be used consistently over several months to see results.</p> <p>Scientists don’t know exactly how minoxidil works. It may affect the different phases of the hair life cycle, thereby encouraging growth. It also <a href="https://www.tandfonline.com/doi/full/10.1080/09546634.2021.1945527?casa_token=KhIM_u0u8nwAAAAA:5njp_XE5cHhip454ycvU1p9p_t0VVzpjRu0ozDZ9YqNb04fmhmngWzYeiowZcG5UugLQkTVIzCcj7A">opens up blood vessels</a> near hair follicles.</p> <p>This increases blood flow, which in turn delivers more oxygen and nutrients to the hair.</p> <p>While minoxidil is unlikely to restore a full head of thick, lush, hair, it can slow down hair loss and can <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007628.pub4/full?highlightAbstract=minoxidil">stimulate regrowth</a>.</p> <p>It is the over-the-counter option with the most evidence. Two strengths are available: 5% and 2%.</p> <p>An analysis of randomised controlled trials found minoxidil applied to the scalp twice a day increased the number of hairs per square centimetre by <a href="https://pubmed.ncbi.nlm.nih.gov/28396101/">eight to 15 hairs</a>, with the higher strength treatment having a slightly greater effect.</p> <h2>Can I use it for non-genetic balding?</h2> <p>There are many causes of hair loss. The main cause in both males and females is a hereditary condition called androgenic alopecia.</p> <p>Although topical minoxidil is only approved for use in Australia for androgenic alopecia, there is some evidence it can also help in other conditions that cause hair loss.</p> <p>For example, it may hasten hair regrowth in patients who have lost hair due to <a href="https://www.jaad.org/article/S0190-9622(96)90500-9/abstract">chemotherapy</a>.</p> <p>Unfortunately, minoxidil is not effective when the hair follicle is gone, like after a burn injury.</p> <p>Although small studies have found promising results using minoxidil to promote hair growth on the face (for <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.13312">beard</a> or <a href="https://pubmed.ncbi.nlm.nih.gov/24471459/">eyebrow</a> enhancement), topical minoxidil products are not currently approved for this use. More research is required.</p> <h2>What else do I need to know?</h2> <p>Minoxidil won’t work well for everyone. Early in treatment you might notice a temporary increase in <a href="https://pubmed.ncbi.nlm.nih.gov/22409453/">hair shedding</a>, as it alters the hair cycle to make way for new growth. Minoxidil needs to be trialled for three to six months to determine if it’s effective.</p> <p>And as it doesn’t cure hair loss, you must <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.14624?casa_token=P-zW7kDNRs8AAAAA%3AaUgUzxU7lbwBpg1BYPajOfXFhpb_mU5g_ounZ6GtjsLLkHO_AdVQ2Kf-8zZkW80ykBj3N_sOsyn392uc">continue</a> to use it each day to maintain the effect. If you stop, you will start losing the new hair growth <a href="https://www.nps.org.au/assets/medicines/1f8127a5-2a98-4013-a7c3-a53300feb0e5-reduced.pdf">within three to four months</a>.</p> <p>Minoxidil products may not be suitable for everyone. If you have any medical conditions or take any medications, you should speak with your doctor or pharmacist before using minoxidil products.</p> <p>It has not been tested for safety in <a href="https://www.nps.org.au/assets/medicines/1f8127a5-2a98-4013-a7c3-a53300feb0e5-reduced.pdf">people under 18, over 65, or those who are pregnant</a>.</p> <p>You can read the <a href="https://www.nps.org.au/medicine-finder/regaine-for-men-regular-strength-application">consumer medicines information sheet</a> for more information about using over-the-counter minoxidil products.</p> <p>Many people do not like to use minoxidil solution or foams long-term because they need to be applied everyday day, which can be inconvenient. Or they may notice side effects, such as scalp irritation and changes to hair texture.</p> <p>Some people <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.14624?casa_token=P-zW7kDNRs8AAAAA%3AaUgUzxU7lbwBpg1BYPajOfXFhpb_mU5g_ounZ6GtjsLLkHO_AdVQ2Kf-8zZkW80ykBj3N_sOsyn392uc">tolerate the foam products better</a> than the solution, as the solution contains more of a compound called propylene glycol (which can irritate the skin).</p> <h2>What about the oral tablet form of minoxidil?</h2> <p>Minoxidil is also available on prescription as an oral tablet. While traditionally used for high blood pressure, it has also been used as a treatment for hair loss.</p> <p>In 2020, a <a href="https://www.jaad.org/article/S0190-9622(20)32109-5/abstract">systematic review</a> identified 17 studies involving 634 patients using oral minoxidil for various hair loss conditions.</p> <p>The authors found oral minoxidil was effective and generally well tolerated in healthy people who were having trouble using the topical products.</p> <p>The review noted oral minoxidil may increase hair growth over the whole body and may cause heart-related side effects in some patients. More research is required.</p> <p>In Australia, oral minoxidil is available under the trade name <a href="https://www.nps.org.au/assets/medicines/df29e16f-6464-4652-ba1f-a53300fed275.pdf">Loniten</a>®. However, it is currently only approved for use in high blood pressure.</p> <p>When people seek a prescription treatment for a non-approved purpose, this is called “off-label” prescribing. Off-label prescribing of oral minoxidil, potentially for use in alopecia, may have contributed to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170338/">shortages</a> of Loniten® tablets in recent years. This can reduce availability of this medicine for people who need it for high blood pressure.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/223736/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/jacinta-l-johnson-1441348">Jacinta L. Johnson</a>, Senior Lecturer in Pharmacy Practice, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em> and <a href="https://theconversation.com/profiles/kirsten-staff-1494356">Kirsten Staff</a>, Senior Lecturer in Pharmacy, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-minoxidil-the-anti-balding-hair-growth-treatment-heres-what-the-science-says-223736">original article</a>.</em></p> <p><em>Image: Getty</em></p>

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With COVID surging, should I wear a mask?

<p><em><a href="https://theconversation.com/profiles/c-raina-macintyre-101935">C Raina MacIntyre</a>, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a></em></p> <p>COVID is <a href="https://theconversation.com/were-in-a-new-covid-wave-what-can-we-expect-this-time-216820">on the rise again</a>, with a peak likely over the holiday season.</p> <p>Given this, health authorities in a number of Australian states have recommended people start <a href="https://www.thenewdaily.com.au/life/health/2023/11/15/covid-australia-eighth-wave">wearing masks again</a>. In <a href="https://www.abc.net.au/news/2023-11-17/wa-public-hospitals-mask-requirements-roger-cook-covid-19/103120580">Western Australia</a>, masks have been made mandatory in high-risk areas of public hospitals, while they’ve similarly been reintroduced in health-care settings in <a href="https://www.adelaidenow.com.au/coronavirus/mandatory-face-masks-introduced-in-lyell-mcewin-and-modbury-hospitals-as-covid-wave-hits-sa/news-story/b4bad98deb02a66dde4cf866f60b607a">other parts of the country</a>.</p> <p>Hospitals and aged care facilities are definitely the first places where masks need to be reinstated during an epidemic. But authorities are <a href="https://www.thenewdaily.com.au/life/health/2023/11/15/covid-australia-eighth-wave">differing in their recommendations</a> currently. Calls to mask up, particularly in the wider community, <a href="https://www.9news.com.au/national/queensland-covid-chief-health-officer-confirms-covid-wave/a3a92381-bd6f-4175-a366-3b8e0f627990">have not been unanimous</a>.</p> <p>So amid rising COVID cases, should you be wearing a mask?</p> <h2>COVID is still a threat</h2> <p>Unfortunately, SARS-CoV-2 (the virus that causes COVID) has not mutated into just a trivial cold.</p> <p>As well as causing symptoms in the initial phase – which can be especially serious for people who are vulnerable – the virus can lead to <a href="https://www.nature.com/articles/s41579-022-00846-2">chronic illness</a> in people of any age and health status due to its ability to affect blood vessels, <a href="https://academic.oup.com/eurheartjsupp/article/25/Supplement_A/A42/7036729">the heart</a>, lungs, brain and immune system.</p> <p>COVID and its ongoing effects are contributing to <a href="https://www.nature.com/articles/s41591-023-02521-2">substantial disability</a> in society. Loss of productivity due to long COVID is affecting <a href="https://www.mckinsey.com/industries/healthcare/our-insights/one-billion-days-lost-how-covid-19-is-hurting-the-us-workforce">workforce and economies</a>.</p> <p>While public messaging to “live with COVID” has seemingly encouraged us to move on from the pandemic, SARS-CoV-2 has other ideas. It has <a href="https://erictopol.substack.com/p/the-virus-is-learning-new-tricks">continued to mutate</a>, become <a href="https://www.ebgtz.org/resource/omicron-faqs/">more contagious</a>, and to evade the protection offered by vaccines.</p> <p>COVID is not endemic, but is <a href="https://www.cnbc.com/2022/02/02/covid-will-never-become-an-endemic-virus-scientist-warns.html">an epidemic virus</a> like influenza or measles, so we can expect waves to keep coming. With this in mind, it’s definitely worth protecting yourself – particularly when cases are rising.</p> <h2>What can we do to protect ourselves?</h2> <p>We know SARS-CoV-2 transmits <a href="https://www.thelancet.com/article/S0140-6736(21)00869-2/fulltext">through the air</a> we breathe. We also know a lot of the transmission risk is <a href="https://abcnews.go.com/Health/covid-transmission-asymptomatic/story?id=84599810">from people without symptoms</a>, so you can’t tell who around you is infectious. This provides a strong rationale for universal masking during periods of high transmission.</p> <p>The need is highest in hospitals where thousands of unsuspecting patients have caught COVID during the course of the pandemic and <a href="https://www.theage.com.au/national/victoria/a-death-sentence-more-than-600-people-die-after-catching-covid-in-hospital-20230621-p5di7x.html">hundreds have died</a> as a result in Victoria alone. Aged care facilities are similarly vulnerable.</p> <p>Masks <a href="https://theconversation.com/yes-masks-reduce-the-risk-of-spreading-covid-despite-a-review-saying-they-dont-198992">do work</a>. A Cochrane review suggesting they don’t was flawed and subject to <a href="https://www.thestar.com/news/canada/how-the-cochrane-review-went-wrong-report-questioning-covid-masks-blows-up-prompts-apology/article_80b67196-5872-5b1a-a208-b0a525f8de5b.html">an apology</a>.</p> <p>Masks work equally by protecting others and protecting you. By visualising human exhalations too tiny to see with the naked eye, my colleagues and I showed how masks <a href="https://theconversation.com/which-mask-works-best-we-filmed-people-coughing-and-sneezing-to-find-out-143173">prevent outward emissions</a> and how each layer of a mask improves this.</p> <p>The most protective kind of mask is <a href="https://theconversation.com/time-to-upgrade-from-cloth-and-surgical-masks-to-respirators-your-questions-answered-174877">a respirator or N95</a>, but any mask protects <a href="https://www.cdc.gov/mmwr/volumes/71/wr/mm7106e1.htm">more than no mask</a>.</p> <p>Wearing a mask when visiting health-care or aged-care facilities is important. Wearing a mask at the shops, on public transport and in other crowded indoor settings will improve your chances of having a COVID-free Christmas.</p> <h2>What about vaccines?</h2> <p>Although the virus’ evolution has challenged vaccines, they remain very important. Boosters will improve protection because vaccine immunity wanes and new mutations make older vaccines less effective.</p> <p>In May 2023 the <a href="https://www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines">World Health Organization</a> outlined why <a href="https://erictopol.substack.com/p/the-ba286-variant-and-the-new-booster">monovalent boosters</a> matched to a single current circulating strain gives better protection than the old bivalent boosters (which target two strains). The XBB boosters are available <a href="https://www.sbs.com.au/news/article/the-covid-19-vaccines-australians-cant-get-yet/ueac5puue">in the United States</a>, and will be available in Australia <a href="https://www.health.gov.au/ministers/the-hon-mark-butler-mp/media/new-covid-19-vaccines-available-to-target-current-variants?language=en">from December 11</a>.</p> <p>Testing and treatment will also help. There are effective antivirals for COVID, but you cannot get them without a COVID test, and <a href="https://theconversation.com/were-in-a-new-covid-wave-what-can-we-expect-this-time-216820">testing rates</a> are very low. Having some RAT tests on hand means you can quickly isolate and get antivirals if indicated.</p> <p>Finally, safe indoor air is key. Remember that SARS-CoV-2 spreads silently, mainly by inhaling contaminated air. Opening a window or using an air purifier can significantly reduce your risk, especially in crowded indoor settings <a href="https://iopscience.iop.org/article/10.1088/2752-5309/ace5c9">like schools</a>. A <a href="https://ozsage.org/media_releases/">multi-layered strategy</a> of vaccines, masks, safe indoor air, testing and treatment will help us navigate this COVID wave.</p> <hr /> <p><em>Editor’s note: This article has been updated to reflect the announcement that monovalent XBB 1.5 vaccines will be deployed as part of Australia’s COVID vaccination program.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/217902/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></em></p> <p><em><a href="https://theconversation.com/profiles/c-raina-macintyre-101935">C Raina MacIntyre</a>, Professor of Global Biosecurity, NHMRC Principal Research Fellow, Head, Biosecurity Program, Kirby Institute, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/with-covid-surging-should-i-wear-a-mask-217902">original article</a>.</em></p>

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"What have I done?!" Sandra Sully opens up on her big Masked Singer reveal

<p>Beloved TV personality Sandra Sully <a href="https://www.dailytelegraph.com.au/entertainment/television/sandra-sully-reveals-how-she-broke-down-with-anxiety-on-the-masked-singer-australia/news-story/6b2aa31a7eab6c3c567005803937fa6d" target="_blank" rel="noopener">recently shared her candid experience</a> of battling anxiety while participating in <em>The Masked Singer Australia – </em>one of the most anticipated and highly publicised reveals in the history of the show.</p> <p>According to the Daily Mail, the 10 News presenter found herself regretting her decision to join the reality show, and contemplated ways to back out. “I literally broke down in tears after a singing lesson, thinking ‘what have I done?’,” she told the publication.</p> <p>Then, in the midst of all this turmoil and anxiety, Sully had a pivotal moment after a singing lesson. Overwhelmed by self-doubt, she broke down in tears, questioning the wisdom of her choice to be on the show at all.</p> <p>She repeatedly voiced her concerns to her husband, Symon Brewis-Weston, saying, "What have I done? I can't do it, I can't do it – what am I going to do?"</p> <p>It was Brewis-Weston who provided her with the much-needed encouragement. He had initially convinced her to participate after years of declining offers from producers. He sternly advised her to stop spiralling into negativity, reminding her of the reasons she had said yes to the show and encouraging her to embrace the experience with a sense of fun. He told her, "Just have a bit of fun. No one's going to die, including you."</p> <p>Sully took his advice to heart, realising that her anxiety was getting the best of her. She had a moment of self-reflection and decided to stop doubting herself.</p> <p>Sully's big reveal as the Fawn character, designed by Tim Chappel, was a shock to the show's panellists  Mel B, Abbie Chatfield, Dave Hughes and Chrissie Swan, who had not heard her sing during her more than 30-year career in news presentation.</p> <p>Sully's lack of singing experience surprised not only the viewers but also her husband and friends, as she never sang in the shower and only had experience as a drummer in her primary school band. She humorously admitted, "I don't sing along in the car – I probably can now because I've shown Australia I can't sing. So we can all laugh out loud together as I also laugh at myself."</p> <p>Relieved that her <em>Masked Singer</em> journey is over, Sully faced additional challenges beyond anxiety, including the need to constantly tell fibs to friends and colleagues in order to conceal her identity. She also grappled with claustrophobia, particularly once the heavy mask was placed on her head.</p> <p>Describing the experience, she said, "Your whole head is ensconced like in a balaclava, and then you have to put this mask on and it's done up under your chin, and then tightened like a bike helmet underneath it so it all fits your head." The show forced her to confront various personal fears beyond performing and singing.</p> <p>Although Sully is open to pushing her boundaries and venturing outside her comfort zone, she has firmly declined offers to appear on Ten's <em>I'm A Celebrity ... Get Me Out Of Here</em>, citing her severe claustrophobia and fear of snakes as insurmountable obstacles.</p> <p>She is grateful for choosing <em>The Masked Singer</em> as her reality show adventure, where she had the opportunity to have fun despite the challenges.</p> <p><em>Images: Network Ten</em></p>

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Huge news for avid cruisers

<p>Those planning to embark on a cruise can leave their masks behind, as Covid mandates on board have finally been scrapped. </p> <p>NSW premier Chris Minns announced the change of rules for cruise passengers on Monday, saying, “We need to get life back to normal.”</p> <p>Previously, the rules around cruising were quite strict in the face of several Covid outbreaks on ships around the world, with passengers over the age of 12 needing to provide proof of vaccination prior to embarking. </p> <p>Travellers also had to abide by enforced mask-wearing when embarking and disembarking the ship, and had to present a negative Covid test prior to departure.</p> <p>The NSW government announced on Monday that they had formally signed paperwork that removed the rules from the Eastern Seaboard and Western Australian Cruise Protocols, which also covers travellers embarking from Victoria, Queensland and Western Australia.</p> <p>Mr Minns said it was time to “get life back to normal”.</p> <p>“We have scrapped these rules because they aren’t needed anymore,” he said.</p> <p>“Passengers can take their own decisions to look after their health before and during a cruise.”</p> <p>Tourism Minister John Graham welcomed the change in regulations, but also thanked the government for implementing the safety rules at the height of the Covid pandemic. </p> <p>“The 2023 winter cruise season in Sydney is on track to be one of the strongest on record and it is fantastic even more people can now participate,” he said. </p> <p>“These protocols were important after Covid but were not intended to continue in perpetuity and I thank the sector for how they have handled the additional requirements placed upon them.”</p> <p>While the remaining states have yet to formally rescind the rules, the federal health body has advocated for the removal of the Covid public health measures.</p> <p><em>Image credits: Getty Images</em></p>

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9 signs you have inflammation in your body. Could an anti-inflammatory diet help?

<p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a></em></p> <p>There is a lot of health buzz around the term “inflammation” right now. From new scientific <a href="https://medicalxpress.com/news/2023-07-inflammation-discovery-aging-age-related-diseases.html">discoveries</a> to <a href="https://people.com/health/gwyneth-paltrow-addresses-backlash-anti-inflammatory-diet/">celebrities</a> and social media influencers, it seems like everyone is talking about this important bodily process and its potential impact on our health.</p> <p>“<a href="https://www.nature.com/articles/s41574-018-0059-4">Inflammaging</a>” is a specific term you may also have seen. It’s an age-related increase in persistent, low-grade inflammation in blood and tissue, which is a strong risk factor for many conditions and diseases.</p> <p>So, can an anti-inflammatory diet help reduce inflammation? Let’s take a look.</p> <h2>What is inflammation?</h2> <p>When our body becomes injured or encounters an infection, it activates defence mechanisms to protect itself. It does this by instructing our cells to fight off the invader. This fighting process <a href="https://www.nature.com/articles/s41591-019-0675-0#citeas">causes inflammation</a>, which often presents as swelling, redness and pain.</p> <p>In the short-term, inflammation is a sign your body is healing, whether from a grazed knee or a cold.</p> <p>If inflammation persists for a longer time it’s called “chronic”. That can indicate a <a href="https://www.nature.com/articles/s41467-018-05800-6">health problem</a> such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638313/">arthritis</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719998/#B2-ijms-20-03879">heart disease</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523054/">diabetes</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/">dementia</a> or other autoimmune disorders.</p> <p>The <a href="https://www.ncbi.nlm.nih.gov/books/NBK493173/">signs and symptoms</a> of chronic inflammation may be present from several months to years and include:</p> <ol> <li>persistent pain</li> <li>chronic fatigue or insomnia</li> <li>joint stiffness</li> <li>skin problems</li> <li>elevated blood markers (such as <a href="https://www.healthdirect.gov.au/c-reactive-protein-CRP-blood-test">C-reactive protein</a>)</li> <li>gastrointestinal issues (constipation, diarrhoea, acid reflux)</li> <li>depression, anxiety and mood disorders</li> <li>unintended weight gain or loss</li> <li>frequent colds or flu.</li> </ol> <h2>What role does diet play?</h2> <p>The relationship between food and inflammation is <a href="https://www.sciencedirect.com/science/article/pii/S0735109706013350">well recognised</a>. Overall, some food components may activate the immune system by producing pro-inflammatory cytokines (small proteins important in cell signaling) or reducing the production of anti-inflammatory cytokines.</p> <p>A “<a href="https://theconversation.com/clear-evidence-for-a-link-between-pro-inflammatory-diets-and-27-chronic-diseases-heres-how-you-can-eat-better-158451">pro-inflammatory diet</a>” may increase inflammation in the body over the long term. Such diets are usually low in fresh produce like fruits, vegetables and wholegrains, and high in commercially baked goods, fried foods, added sugars and red and processed meats.</p> <p>In contrast, an “<a href="https://academic.oup.com/ajcn/article/80/4/1029/4690355">anti-inflammatory</a>” diet is associated with less inflammation in the body. There is no single anti-inflammatory diet. Two well-recognised, evidence-backed examples are the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet.</p> <p>Anti-inflammatory diets typically include the following elements:</p> <p><strong>1. high in antioxidants.</strong> These compounds help the body fight free radicals or unstable atoms, that in high quantities are linked to illnesses such as cancer and heart disease. The best way to consume antioxidants is by eating lots of fruits and vegetables. Research shows frozen, dried and canned fruits and vegetables can be <a href="https://theconversation.com/frozen-and-tinned-foods-can-be-just-as-nutritious-as-fresh-produce-heres-how-201740">just as good as fresh</a></p> <p><strong>2. high in “healthy”, unsaturated fatty acids.</strong> Monounsaturated fats and omega-3-fatty acids are found in fish (sardines, mackerel, salmon and tuna), seeds, nuts, and plant-based oils (olive oil and flaxseed oil)</p> <p><strong>3. high in fibre and prebiotics.</strong> Carrots, cauliflower, broccoli and leafy greens are good sources of fibre. Prebiotics promote the growth of beneficial microorganisms in our intestines and can come from onions, leeks, asparagus, garlic, bananas, lentils and legumes</p> <p><strong>4. low in processed foods.</strong> These contain refined carbohydrates (pastries, pies, sugar-sweetened beverages, deep-fried foods and processed meats).</p> <h2>Rheumatoid arthritis, dementia, depression</h2> <p>There is mixed evidence for the role of anti-inflammatory diets in rheumatoid arthritis pain management. A recent <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706441/">2021 systematic review</a> (where researchers carefully group and examine the available evidence on a topic) found eating an anti-inflammatory diet likely leads to significantly lower pain in people with rheumatoid arthritis when compared with other diets.</p> <p>However, the 12 studies included in the review had a high risk of bias – likely because people knew they were eating healthy foods – so the confidence in the evidence was low.</p> <p>Inflammation is strongly implicated in the development of neurodegenerative diseases like <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486891/">Alzheimer’s disease and related dementia</a> and evidence suggests anti-inflammatory diets might help to protect the brain.</p> <p>A <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015034/">2016 review</a> showed an anti-inflammatory diet may be protective against cognitive impairment and dementia, but that further large randomised controlled trials are needed. A <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673721/">2021 study</a> followed 1,059 people for three years and observed their diet. They reported those with a greater pro-inflammatory diet had an increased risk of developing dementia.</p> <p>Inflammation has also been linked with mental health, with people eating a pro-inflammatory diet reporting more symptoms of <a href="https://pubmed.ncbi.nlm.nih.gov/31152670/">depression</a>. Diet is the fundamental element of <a href="https://www1.racgp.org.au/ajgp/2019/october/lifestyle-interventions-for-mental-health">lifestyle approaches</a> to managing anxiety and mental health.</p> <p>More broadly, a <a href="https://www.mdpi.com/2227-9059/9/8/922">2021 review paper</a> examined recent research related to anti-inflammatory diets and their effect on reducing inflammation associated with ageing. It found compounds commonly found in anti-inflammatory diets could help alleviate the inflammatory process derived from diseases and unhealthy diets.</p> <h2>What about turmeric?</h2> <p>A favourite on social media and vitamin shelves, turmeric is promoted as having anti-inflammatory benefits. These are linked to a specific compound called <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388087/#:%7E:text=Curcuminoids%20are%20phenolic%20compounds%20commonly,several%20important%20functions%20of%20curcuminoids.">curcumin</a>, which gives turmeric its distinctive yellow colour.</p> <p>Research suggests curcumin might act as an anti-inflammatory agent in the body but high-quality clinical trials in humans are <a href="https://www.mdpi.com/1420-3049/16/6/4567">lacking</a>. Most of the <a href="https://www.mdpi.com/1420-3049/16/6/4567">existing studies</a> have been conducted in <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.27360">lab settings</a> using cells or in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608712/">animals</a>. So it’s unclear how much curcumin is needed to see anti-inflammatory benefits or how well <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/">we absorb it</a>.</p> <p>Overall, adding turmeric to your food may provide your body with some health benefits, but don’t rely on it to prevent or treat disease on its own.</p> <h2>Safe eating</h2> <p>Inflammation is a major factor in the link between diet and many health conditions.</p> <p>Eating an anti-inflammatory diet is considered safe, likely to support health and to prevent future chronic conditions. If you are looking for tailored dietary advice or an anti-inflammatory meal plan, it’s best to speak with an <a href="https://member.dietitiansaustralia.org.au/Portal/Portal/Search-Directories/Find-a-Dietitian.aspx">accredited practising dietitian</a>.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/210468/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, Professor of Community Health and Wellbeing, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, Dietitian, Researcher &amp; Lecturer, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/9-signs-you-have-inflammation-in-your-body-could-an-anti-inflammatory-diet-help-210468">original article</a>.</em></p>

Body

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Anti-vegan chef launches clothing line against activist

<p dir="ltr">Chef John Mountain has taken his feud with vegan activist Tash Peterson to the next level by unveiling a clothing line that names and shames her and her animal rights beliefs. </p> <p dir="ltr">The Perth chef, who has taken legal action against Ms Peterson after the pair tussled during protests at his restaurant Fyre, showed off the provocative range of tank-tops, t-shirts and hoodies on his new merchandise website.</p> <p dir="ltr">The merch page, which was launched on Saturday, promises customers will love the clothing “hopefully more than Tash loves chef”.</p> <p dir="ltr">It is now selling clothing that carries the restaurant's branding and slogans such as “Pleased to meat stew”, “no animals were harmed in the making of this shirt” and “all they have done is added fuel to the Fyre”.</p> <p dir="ltr">One t-shirt design features a half-star Google-style review graphic with the words: “Absolutely f***ing chaotic Tash Peterson”, which makes fun of Ms Peterson's description of a protest and the flood of Fyre reviews posted by vegans.</p> <p dir="ltr">Another design asks. “What's the difference between a vegan and a heroin addict? The vegan keeps it to themselves.”</p> <p dir="ltr">The clothing line comes after John Mountain announced all vegans would be banned from his restaurant due to “mental health reasons”.</p> <p dir="ltr">Mountain and Peterson have clashed several times at the Perth eatery, with Peterson’s latest demonstration resulting in legal action being taken against the staunch vegan and animal rights activist. </p> <p dir="ltr">After Peterson <a href="https://oversixty.com.au/finance/legal/furious-chef-lets-loose-after-clash-with-vegan-protestors" target="_blank" rel="noopener">stormed</a> his booked-out restaurant with other activists in tow, they stood outside with a megaphone, while shouting and playing sounds of squealing pigs, moments before the altercation was caught on camera.</p> <p dir="ltr">Mountain and Peterson came to physical blows as he wrestled them out of the restaurant, as he defended his choice to retaliate against the protestors, saying he chose to stand up to the bullies to "protect my business". </p> <p dir="ltr">"Bullies come in all different shapes and sizes and these lot just happen to be the vegans."</p> <p dir="ltr"><em>Image credits: A Current Affair / Fyre</em></p>

Legal

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Who’s taking COVID antivirals like Paxlovid? Hint: it helps if you’re rich

<p><em><a href="https://theconversation.com/profiles/nicole-allard-1349026">Nicole Allard</a>, <a href="https://theconversation.com/institutions/the-peter-doherty-institute-for-infection-and-immunity-2255">The Peter Doherty Institute for Infection and Immunity</a></em></p> <p>When it comes to COVID, people living in disadvantaged communities are hit with a triple whammy. First, they’re <a href="https://www.aihw.gov.au/reports-data/health-conditions-disability-deaths/covid-19/overview">more likely</a> to get infected, and when sick, are more likely to have serious disease. Second, they’re <a href="https://theconversation.com/first-covid-hit-disadvantaged-communities-harder-now-long-covid-delivers-them-a-further-blow-183908">more likely</a> to develop long COVID. Third, our <a href="https://www.mja.com.au/journal/2023/218/10/access-oral-covid-19-antivirals-community-are-eligibility-criteria-and-systems">recent research</a> suggests they’re less likely to get antivirals and when they do, it’s on average later.</p> <p>We’ve just <a href="https://www.mja.com.au/journal/2023/218/10/access-oral-covid-19-antivirals-community-are-eligibility-criteria-and-systems">published the data</a> to map how disadvantage is linked with access to COVID antiviral drugs you can take at home.</p> <p>Here’s why our findings matter and what we can do to level the playing field for this critical part of Australia’s COVID response.</p> <h2>What we did and what we found</h2> <p>Our team looked at Victorian and national prescribing data trends for the oral antiviral medications eligible Australians can take at home – Paxlovid (nirmatrelvir/ritonavir) and Lagevrio (molnupiravir).</p> <p>My health department colleagues linked data from the Pharmaceutical Benefits Scheme with information from the Victorian health department’s COVID surveillance database. They then matched levels of socioeconomic disadvantage by postcode, according to criteria from the Australian Bureau of Statistics.</p> <p>Their analysis showed people living in the most disadvantaged postcodes were 15% less likely to receive oral antivirals compared with those in the most advantaged postcodes.</p> <p>Those in the most disadvantaged postcodes were supplied with the antivirals on average a day later (three days versus two days) than those in the most advantaged postcodes.</p> <p>There are some limitations to our analysis. Not everyone who tests for COVID reports their positive result. And we suspect there may be more under-reporting of infections in disadvantaged areas.</p> <p>Nevertheless, our findings about the influence of disadvantage on antiviral supply are not surprising. In the United States, there have been <a href="https://www.cdc.gov/mmwr/volumes/71/wr/mm7125e1.htm?utm">similar results</a>.</p> <h2>Why has this happened?</h2> <p>We know <a href="https://www.health.gov.au/health-alerts/covid-19/treatments/eligibility">early access to antivirals</a>, within the first five days of symptoms starting, is important to reduce the chances of severe disease and hospitalisation in those at risk.</p> <p>So why are people in disadvantaged areas less likely to have access to COVID antivirals? The answers are multiple and complex.</p> <p>Some relate to <a href="https://link.springer.com/article/10.1007/s11069-019-03584-6/tables/1">disadvantage</a> that existed before the pandemic – for instance, poverty, homelessness, lower levels of English or formal education, and being less likely to have a regular GP.</p> <p>Some factors relate specifically to antivirals. For instance, to access antivirals, you first have to know they exist and whether you might be eligible, then know how to access them and when. There may be out-of-pocket costs to see a GP to be assessed, then there’s the cost of filling the prescription, even with a concession card.</p> <h2>How can we address this?</h2> <p>We have an opportunity to address this inequity, whether that’s by addressing social determinants of health more broadly, or specifically related to antivirals access.</p> <p>Equity depends on continuing to address the structural inequalities in our health system that create barriers to people accessing primary health services, and tailoring responses to communities.</p> <p>For instance, earlier in the pandemic we saw funding to house homeless people, provide COVID-related health care to non-English speaking communities, and for people isolated at home. These initiatives need to continue.</p> <p>Other countries have also recognised the need for more equitable access to COVID antivirals. Initiatives have included:</p> <ul> <li> <p>COVID medicine <a href="https://phlgroup.co.uk/our-services/cmdu/">delivery units</a> in the United Kingdom. These identify, triage and arrange for high-risk people to receive antivirals at home</p> </li> <li> <p><a href="https://covid19.govt.nz/testing-and-isolation/if-you-have-covid-19/medicines-to-treat-covid-19">pharmacists prescribing antivirals</a> in New Zealand, and</p> </li> <li> <p>“<a href="https://aspr.hhs.gov/TestToTreat/Pages/default.aspx#:%7E:text=To%20find%20a%20participating%20Test%20to%20Treat%20site%20near%20you%3A&amp;text=Call%20the%20Centers%20for%20Disease,more%20than%20150%20other%20languages.">test to treat</a>” services in the US. This is where people can get tested, assessed and access antivirals in one spot, in one visit.</p> </li> </ul> <h2>What needs to happen next?</h2> <p>As <a href="https://theconversation.com/were-in-another-covid-wave-but-its-not-like-the-others-206493">COVID waves continue</a>, we must focus on reducing deaths and hospitalisations. Antiviral treatments are part of our armour and equity must drive our response.</p> <p>Our ongoing COVID response should be designed with consumer input, supported by an adequately funded public health system and be data driven. Here’s what needs to happen next:</p> <ul> <li> <p>encourage a tired public to see COVID testing as an important first step to accessing antiviral treatment, and why they should consider treatment</p> </li> <li> <p>address the health care inequality in primary care (for instance, boosting timely access to a GP people can afford to visit) by increasing resourcing in areas where we know there are gaps</p> </li> <li> <p>provide culturally safe health care, delivered in community languages, co-designed with community input</p> </li> <li> <p>evaluate current and future antiviral medications</p> </li> <li> <p>communicate up-to-date information to the public and health professionals about antivirals, particularity GPs</p> </li> <li> <p>access more data on the coverage and equity of antiviral COVID treatments, to help direct us to the gaps in the health system that need to be plugged.</p> </li> </ul> <h2>Why this matters now</h2> <p>For many of us in the past year, COVID has become another “cold” we encounter and may not even bother testing. Yet, we continue to see <a href="https://www.health.gov.au/health-alerts/covid-19/weekly-reporting">deaths and hospitalisations</a> across the country.</p> <p>Serious COVID infections continue to affect our most vulnerable people. These include elderly people, especially those over 80, First Nations people, people living with a disability and people who are socioeconomically disadvantaged.</p> <p>We have a chance to ensure antivirals are used to reduce existing disparities in hospitalisation and death – not to make them worse.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/207822/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/nicole-allard-1349026">Nicole Allard</a>, Post doctoral researcher and medical epidemiologist, <a href="https://theconversation.com/institutions/the-peter-doherty-institute-for-infection-and-immunity-2255">The Peter Doherty Institute for Infection and Immunity</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/whos-taking-covid-antivirals-like-paxlovid-hint-it-helps-if-youre-rich-207822">original article</a>.</em></p>

Caring

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"I'm glad you're resigning": Kochie's run-in with a heckler

<p>David Koch has shared the details of a nasty altercation he had with a stranger after announcing his departure from <em>Sunrise</em>. </p> <p>Kochie <a href="https://oversixty.com.au/news/news/the-world-s-best-job-kochie-quits-sunrise" target="_blank" rel="noopener">announced</a> on Monday that he would be leaving the Channel Seven breakfast show after 20 years in the hosting chair. </p> <p>The response to his shock resignation has been mostly positive and supportive, as famous friends and loyal viewers have flooded online spaces with well wishes for the veteran TV presenter. </p> <p>However, Kochie shared that after taping had finished for Monday morning's show, he was approached by a heckler on the street while walking with his wife, Libby.</p> <p>“In all of that lovely euphoria, this is just life, I’m walking to lunch with Lib and walked by a bloke and he goes, ‘I’m glad you’re resigning, you are just a paid mouthpiece for Big Pharma’,” Koch said.</p> <p>“An anti-vaxxer. He started yelling at me across the road. Lib’s going ‘What the hell?’.”</p> <p>Koch’s co-host Natalie Barr said, “We take the good with the bad, and we know that.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Kochie has thanked all the well-wishers who responded to the news he is leaving Sunrise, before revealing one random heckler gave him a send-off to forget! <a href="https://twitter.com/kochie_online?ref_src=twsrc%5Etfw">@kochie_online</a> <a href="https://twitter.com/hashtag/kochie?src=hash&amp;ref_src=twsrc%5Etfw">#kochie</a> <a href="https://twitter.com/hashtag/sunriseon7?src=hash&amp;ref_src=twsrc%5Etfw">#sunriseon7</a> <a href="https://t.co/uhUhxONeNN">pic.twitter.com/uhUhxONeNN</a></p> <p>— Sunrise (@sunriseon7) <a href="https://twitter.com/sunriseon7/status/1663321697208918018?ref_src=twsrc%5Etfw">May 29, 2023</a></p></blockquote> <p>Speaking to <a href="https://www.news.com.au/entertainment/tv/morning-shows/david-koch-reveals-he-was-brutally-sledged-in-street-after-quitting-sunrise/news-story/551069985f00f3a4909a32502b4aae91" target="_blank" rel="noopener"><em>news.com.au</em></a>, Koch said that after decades in the game, he was okay with not pleasing everybody.</p> <p>“Yes, we all have faults. I’ve stuffed up and people love me or hate me, but what they see is what they get, and I think they respect that even if they disagree with your views,” he said.</p> <p>“It’s a really intimate relationship with the viewers.”</p> <p>Despite the heckler, Kochie went on to say he had received a lot of kind messages, with one of the nicest tributes coming form his breakfast TV show rival Karl Stefanovic. </p> <p>“A wonderful, classy, respectful [message] from Karl Stefanovic was so nice, really adored that one,” he said on-air.</p> <p>“But so many great messages.”</p> <p><em>Image credits: Sunrise</em></p> <div class="media image" style="caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; box-sizing: inherit; display: flex; flex-direction: column; align-items: center; width: 705.202209px; margin-bottom: 24px; max-width: 100%;"> </div>

TV

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The best anti-ageing secrets dermatologists won’t tell you for free

<p><strong>The best tips from top dermatologists </strong></p> <p>A wide array of over-the-counter anti-ageing skincare products aim to improve the signs of ageing, such as skin spots, fine lines, wrinkles, and boost collagen. Yet, most of these products are more hype – it’s important for consumers to understand when a product is a cosmetic, drug, or both to evaluate the validity of these claims. So, which products can actually deliver results that improve the signs of ageing?</p> <p>We spoke with medical experts who told us the best anti-ageing secrets for better skin health.</p> <p><strong>Opt for sunscreen to fight ageing skin</strong></p> <p>Sunscreen is one of the best weapons when it comes to protecting your skin against skin cancer, and it’s also one of the best ways to keep your skin looking younger and healthier. “The sun emits ultraviolet radiation that damages skin, both the overlying epidermis and the underlying dermis,” explains dermatologist, Dr Jerome Garden. “In addition to increasing your risk of skin cancer, the sun causes brown spots, red spots, and wrinkles.”</p> <p><strong>Expensive products are not always more effective</strong></p> <p>It may be tempting to splurge on a skin-care item that promises to yield worthy results, but pricey doesn’t always equal quality. There are some great inexpensive products that can produce great results, according to dermatologist, Dr Dendy Engelman. “A higher price tag can mean better quality ingredients or a higher concentration of an ingredient, but the ingredients list is always more important than the brand selling the product,” she says.</p> <p><strong>Don't buy generic skincare</strong></p> <p>You don’t need to spend a fortune to get a high-quality skincare product, but there is a difference between a brand name product and a generic one, according to dermatologist, Dr Joshua Zeichner.</p> <p>“Many generic products are packaged to look similar to the original, and may even have the same ingredients list, however, the difference is the quality of the ingredients and how they are actually formulated,” he says.</p> <p><strong>Skimp on a fancy cleanser</strong></p> <p>No matter what an expensive cleanser may cost, it’s not going to work any more magic than most lower-cost competitors, according to dermatologists. “The goal of a cleanser is to remove dirt, oil, makeup and pollution from the skin without disrupting the outer skin layer – and the ingredients used to create a product that can do this are not expensive,” says Dr Zeichner. “In fact, some of the best quality cleansers are actually among the least expensive products on the market.”</p> <p><strong>Opt for a serum</strong></p> <p>Serums, which are meant to be layered underneath your daily and nightly moisturiser, often are the first skincare products to be skipped. But, they actually play an important role in your daily routine. “Serums contain a high concentration of active ingredients and are lightweight, so they penetrate deeper into your skin to provide maximum benefits,” says dermatologist, Dr Whitney Bowe.</p> <p>She recommends looking for serums that contain ceramides and amino acids, which help to bolster the skin’s natural barrier, and antioxidants, which protect skin from sun damage and free radicals.</p> <p><strong>Don't trust anti-wrinkle face cream claims </strong></p> <p>“We develop fine lines because of repeated folding of the skin from underlying muscles,” explains Dr Zeichner. “Young, healthy skin has a strong foundation that resists folding and bounces back to its original shape, but, with age, that skin foundation gets weaker.”</p> <p>While topical creams will certainly help keep the skin barrier strong, the only way to truly reduce wrinkles is to relax the muscles underneath the skin, according to Dr Zeichner.</p> <p><strong>Wear sunscreen year-round</strong></p> <p>It’s true that even on the cloudiest or snowiest of days, sunscreen should be a part of your daily skincare routine. “Incidental sun exposure for only 10 to 15 minutes a day adds up over time and can cause significant sun damage and accelerated photoaging,” says Dr Engelman.</p> <p>In order to keep skin looking its youngest and healthiest, she recommends applying sunscreen every single day of the year, as brief sun exposures throughout the year can add up to significant damage (think driving with the sunroof open or walking around outdoor shopping centres during peak sun hours).</p> <p><strong>Use retinol - it really works</strong></p> <p>According to dermatologist, Dr Hadley King, topical retinoids are the most effective topical anti-ageing products (after sun protection). “There is great data that supports their effectiveness and safety,” she says. “While prescription retinoids are the most effective, there are now plenty of over-the-counter products that contain retinol and work well, especially on those with sensitive skin.”</p> <p><strong>Invest in laser treatments</strong></p> <p>If you’re looking for fast results without the use of creams, Dr Garden recommends laser treatments, which he specialises in. “We have lasers for brown spots, red spots, blood vessels and wrinkles,” he says. “Newer devices called fractionated lasers can produce impressive results with less downtime than before.” Although they’re on the pricier side, he says that these treatments can offer results far superior to creams.</p> <p>But the only caveat is that these machines are powerful and, in many states, can be operated by unqualified individuals who are not even physicians. He recommends making sure that your laser treatments are being performed by a board-certified dermatologist to avoid complications.</p> <p><strong>Try collagen supplements </strong></p> <p>Collagen is a protein that’s a building block for our hair, skin and nails. “Supplemental collagen is fragmented pieces of amino acids and peptides that connect in the bloodstream with enzymes that trigger the production of collagen,” explains Dr Engelman. “In a collagen-deficient system, this will support and increase collagen production.” It’s important, however, that you choose the right type of collagen, since 16 different strains exist.</p> <p>“For oral supplements, hydrolysed collagen is easiest to digest, as it is broken down into the smallest forms of peptides and amino acids,” she says. “I like pills and powders because they are easy to incorporate no matter what your lifestyle.”</p> <p><strong>Don't fall for 'trendy' products</strong></p> <p>The latest and greatest products on the market might be eye-catching, but their popularity doesn’t mean that they’re effective. “Just because something is ‘hot’ right now in the beauty industry, does not mean that you should run out to purchase it,” says Dr Bowe. “I always encourage my patients to look for scientific studies and statistics which prove that products deliver the results they promise.”</p> <p><strong>Follow a healthy diet</strong></p> <p>No matter how much time, energy and money you spend on your skincare regimen, if you’re not supplementing it with a healthy diet, you’re wasting your efforts, according to experts. “Your skin is a reflection of your overall health and wellness and your diet absolutely impacts the appearance and health of your skin,” says Dr Bowe.</p> <p>“For example, sugar in any form causes multiple changes in our body, from our cellular membranes and our arteries to our hormones, immune systems, gut, and even microbiome – the microbes in our intestines that affect our biology all the way out to our skin.”</p> <p><strong>Allergy pill and a nap may reduce dark circles and puffy eyes</strong></p> <p>There are other causes of dark circles that are unrelated to your skin, such as seasonal allergies or lack of sleep. Dermatologist, Dr Joel Schlessinger recommends trying Clarityne or Zyrtec, drinking more water, or heading to bed an hour earlier to clock in more sleep. If your dark circles and puffiness aren’t improved by any of those suggestions, then he says a well-formulated and hydrating eye cream could help.</p> <p><strong>Avoid sleeping on your side</strong></p> <p>Believe it or not, the way you sleep does have an effect on the smoothness of your skin. “Sleeping on your side presses your cheek into the pillow and causes the skin on your chest to be scrunched, creating new or reinforcing existing wrinkles,” warns Dr Schlessinger. “Train yourself to sleep on your back as much as you can – it will keep skin as flat and smooth as possible.”</p> <p><strong>Don't wait until it's too late too start Botox</strong></p> <p>Some fine lines and wrinkles are caused by repetitive movements, so starting these treatments early, even in your late 20s and early 30s, may potentially help prevent them or slow their progression, according to cosmetic dermatologist, Dr Sejal Shah.</p> <p>“People are often afraid of injectables because they don’t want to look ‘frozen’ or overdone, but many neurotoxins (Botox, Dysport, Xeomin, and Jeuveau) can look very natural when appropriately placed.” Just be sure to seek treatment from trained individuals, such as a board-certified dermatologist.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.com.au/healthsmart/beauty/the-best-anti-ageing-secrets-dermatologists-wont-tell-you-for-free?pages=1" target="_blank" rel="noopener">Reader's Digest</a>. </em></p>

Beauty & Style

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“Putrid cookers”: Anti-vaxxers slammed for spreading lies about Jock Zonfrillo’s death

<p dir="ltr">Just hours after MasterChef judge Jock Zonfrillo’s sudden death, heartless anti-vaxxers took to social media to spread disinformation.</p> <p dir="ltr">Zonfrillo died in Melbourne on May 1. While the cause of death has not been publicly announced, police said that his death was not being treated as suspicious, and a report was made for the coroner.</p> <p dir="ltr">The anti-vaxxers took this as a chance to spread disinformation online, implying that his death was linked to the Covid vaccine.</p> <p dir="ltr">“Did Jock Zonfrillo get the Pfizer or Moderna RNA vaccine?” one person tweeted the day after his death.</p> <p dir="ltr">Another commented on the way that his death was described as “sudden” with no confirmed cause- completely ignoring the fact that Zonfrillo’s family have not released that information.</p> <p dir="ltr">“The mainstream media has been reporting countless such ‘sudden deaths’ with ‘no cause of death given’,” wrote the anti-vaxxer on Facebook on May 2.</p> <p dir="ltr">“Since when are death reports being provided with no cause given?</p> <p dir="ltr">“I know since when: since they rolled out those experimental Covid vaccines, which are dropping people faster than they can clue in that it is murdering them. The mainstream media and medical establishment will never admit it – they omit the REAL reason someone died by saying ‘no immediate cause of death was given’,” wrote another.</p> <p dir="ltr">The ill-informed comments have attracted significant backlash from Aussies who slammed the “cookers” for taking advantage of the tragedy to spread disinformation.</p> <p dir="ltr">“Of course the putrid cookers have already come out, saying it was the Covid vaccine that killed Jock Zonfrillo. They really are opportunistic scum. RIP Jock,” one person tweeted in response to the lies.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Of course the putrid cookers have already come out, saying it was the covid vaccine that killed Jock Zonfrillo. <br />They really are opportunistic scum.<br />RIP Jock. <a href="https://t.co/t7jxe9QX1P">pic.twitter.com/t7jxe9QX1P</a></p> <p>— JayJay (@JayJay91341991) <a href="https://twitter.com/JayJay91341991/status/1653215630768865281?ref_src=twsrc%5Etfw">May 2, 2023</a></p></blockquote> <p dir="ltr">“I’m always unsurprised at the amount of cookers that come out of the woodwork when a celebrity dies. Shame on anyone who is using Jock Zonfrillo’s death to push their anti-vax vile rhetoric,” tweeted another.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I’m always unsurprised at the amount of cookers that come out of the woodwork when a celebrity dies. Shame on anyone who is using Jock Zonfrillo’s death to push their anti-vax vile rhetoric.</p> <p>— MrDreeps (@MrDreepy) <a href="https://twitter.com/MrDreepy/status/1652947746419281921?ref_src=twsrc%5Etfw">May 1, 2023</a></p></blockquote> <p dir="ltr">“Distance yourself from people who impulsively attribute the death of a celebrity to the Covid-19 Vaccine.</p> <p dir="ltr">“It demonstrates extreme congruence bias, and a profound lack of empathy. #jockzonfrillo,” wrote a third.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Distance yourself from people who impulsively attribute the death of a celebrity to the Covid-19 Vaccine. </p> <p>It demonstrates extreme congruence bias, and a profound lack of empathy. <a href="https://twitter.com/hashtag/jockzonfrillo?src=hash&ref_src=twsrc%5Etfw">#jockzonfrillo</a></p> <p>— Nick Holt (@realnickholt) <a href="https://twitter.com/realnickholt/status/1652919969926254592?ref_src=twsrc%5Etfw">May 1, 2023</a></p></blockquote> <p dir="ltr"><em>Images: Instagram</em></p> <p dir="ltr"> </p>

News

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"Stay away!": City forced into bizarre anti-travel campaign

<p>Amsterdam has taken desperate measures in the fight to keep the city safe from “messy” tourists determined to cause chaos and call it a night out. </p> <p>The Dutch capital’s new online campaign sets out to primarily tackle the problem of young British men, warning them against their plans to “let loose” while they’re visiting. </p> <p>Hopeful British tourists - between the ages of 18 and 35 - who google things like “stag party Amsterdam”, “pub crawl Amsterdam”, and “cheap hotel Amsterdam” will be made to view short videos that stress the consequences that come with “[causing] nuisance and excessive alcohol and drug use”, according to a statement from the city’s local authorities. </p> <p>One of said videos shows an intoxicated young man being arrested after insulting police officers, with text reading: “Coming to Amsterdam for a messy night + getting trashed = €140 fine + criminal record = fewer prospects.” </p> <p>From there comes the firm and to-the-point statement: “So coming to Amsterdam for a messy night? Stay away.”</p> <p>In another of the campaign’s videos, an unconscious individual can be seen in an ambulance as it rushes to hospital, this time with text that reads: “Coming to Amsterdam to take drugs + lose control = hospital trip + permanent health damage = worried family.” </p> <p>It concludes with the same message as the other. </p> <p>Amsterdam welcomes approximately 20 million tourists each year, and is well known for its red light district. It’s this same hotspot that has played a major role in establishing the city as the place to party in Europe. </p> <p>However, local residents have voiced their displeasure for years, fed up with the chaos that drunken tourists bring their way, and prevent them from enjoying their own city as they want to. </p> <p>“Visitors will remain welcome, but not if they misbehave and cause nuisance. In that case we as a city will say: rather not, stay away,” Amsterdam’s deputy mayor Sofyan Mbarki said.</p> <p>“Amsterdam is already taking lots of measures against excessive tourism and nuisance, and we are taking more measures than other large cities in Europe. But we have to do even more [in] the coming years if we want to give tourism a sustainable place in our city.”</p> <p>From there, he went on to note that in order to keep their city a liveable place, they had to turn their attention to “restriction instead of irresponsible growth.” </p> <p>This isn’t the only - or even first - step city officials have taken towards achieving their goal, having just passed new regulations that make it illegal for anyone to smoke cannabis while in the red light district. </p> <p>The video campaign may yet expand to include visitors from beyond the UK, authorities have suggested. They also plan to launch another campaign called “How to Amsterdam”, which aims to reign in tourists already visiting. This campaign will utilise social media and street signs, with warnings about everything from drunkenness to noise, drugs, and urinating in public. </p> <p>Providers who offer bachelor party experiences have reportedly been contacted by the council as well, in the hope that they can reduce - and prevent - trouble in the city’s centre, while they also await the results of research into a potential tourist tax. </p> <p><em>Images: YouTube</em></p>

Travel Trouble

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Tech millionaire’s “creepy” $100k offer sparks wave of backlash

<p>US tech millionaire and Silicon Valley entrepreneur Steve Kirsch has been slammed for making a “creepy” offer towards a female passenger who was travelling on the same plane.</p> <p>In a tweet, Kirsch claimed that he offered the stranger $US100,000 to remove her face mask for the flight.</p> <p>"I am on board a Delta flight right now. The person sitting next to me in first-class refused $100,000 to remove her mask for the entire flight. No joke," he tweeted.</p> <p>Kirsch, who became infamous for spreading misinformation about the COVID-19 vaccines throughout the pandemic, said that he "explained" to his seatmate that masks "don’t work".</p> <p>He also claims that the woman worked for a pharmaceutical company, and he started by offering her $US100 but worked his way up.</p> <p>She rejected his offer, but Kirsch persisted and said that if she removed the mask to eat and drink she "she could be infected with one breath".</p> <p>Many have slammed the entrepreneur for his actions.</p> <p>“Ew. Do you make a habit of offering money to random women to remove coverings from their bodies mid-air?" posted Jess Piper, a former Democrat state representative nominee, in her response to Kirsch's post.</p> <p>“Stop bugging people who are minding their own business with your creepy nonsense,” commented Alastair McAlpine, an infectious disease expert.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I am on board a Delta flight right now. The person sitting next to me in first class refused $100,000 to remove her mask for the entire flight. No joke. This was after I explained they don’t work. She works for a pharma company. <a href="https://t.co/Q8Hwzhkmxf">pic.twitter.com/Q8Hwzhkmxf</a></p> <p>— Steve Kirsch (@stkirsch) <a href="https://twitter.com/stkirsch/status/1634189428150390785?ref_src=twsrc%5Etfw">March 10, 2023</a></p></blockquote> <p>"This is wildly creepy, you get that, right? Every part of this. From the request, to the expression, to the fact you decided to tweet this!" commented one user.</p> <p>“All you’re doing here is admitting you patronised and harassed a woman who made a decision she thought was best for her,” wrote another.</p> <p>Last week, Kirsch tried to pull the same stunt on a different flight.</p> <p>He tweeted that he offered his seatmates $US10,000 to remove their masks for the flight, but they also declined his offer.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I asked the people sitting next to me on the plane if I paid them $10,000 would they remove their mask for the duration of the flight? Both declined the offer. </p> <p>Maybe I should offer $100,000 next time? This can quantify the amount of brainwashing. <a href="https://t.co/VLlymusmcq">pic.twitter.com/VLlymusmcq</a></p> <p>— Steve Kirsch (@stkirsch) <a href="https://twitter.com/stkirsch/status/1633166204054675456?ref_src=twsrc%5Etfw">March 7, 2023</a></p></blockquote> <p>"Maybe I should offer $100,000 next time? This can quantify the amount of brainwashing," he added.</p> <p>Delta airlines have said that masks are optional for both domestic and international travel unless required by “applicable governments”.</p> <p>American federal law no longer requires masks be worn in airports or on planes, but certain cities and states may still make it a requirement at their airports.</p> <p><em>Image: Twitter</em></p>

Travel Trouble

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Yes, masks reduce the risk of spreading COVID, despite a review saying they don’t

<p>The question of whether and to what extent face masks work to prevent respiratory infections such as COVID and influenza has split the scientific community for <a href="https://www.baltimoresun.com/news/bs-xpm-2007-03-06-0703060040-story.html">decades</a>.</p> <p>Although there is strong evidence face masks <a href="https://www.sciencedirect.com/science/article/pii/S0020748920301139?via%3Dihub">significantly reduce transmission of such infections</a> both in health-care settings and in the community, some experts do not agree.</p> <p>An updated <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006207.pub6/full">Cochrane Review</a> published last week is the latest to suggest face masks don’t work in the community.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">"Wearing masks in the community probably makes little or no difference to the outcome of laboratory‐confirmed influenza/SARS‐CoV‐2 compared to not wearing masks"<a href="https://twitter.com/CochraneLibrary?ref_src=twsrc%5Etfw">@CochraneLibrary</a> Review.<br />Published: 30 January 2023 <a href="https://t.co/zODu6QEF1M">https://t.co/zODu6QEF1M</a> <a href="https://t.co/c26yHPaSCD">pic.twitter.com/c26yHPaSCD</a></p> <p>— Robin Monotti (@robinmonotti) <a href="https://twitter.com/robinmonotti/status/1620311528523304960?ref_src=twsrc%5Etfw">January 31, 2023</a></p></blockquote> <p>However there are problems with the review’s methodology and its underpinning assumptions about transmission.</p> <p>The Cochrane Review combined randomised controlled trials (RCTs) using <a href="https://ebn.bmj.com/content/16/1/3">meta-analysis</a>. RTCs test an intervention in one group and compare it with a “control” group that doesn’t receive the intervention or receives a different intervention. A meta-analysis pools the results of multiple studies.</p> <p>This approach assumes (a) RCTs are the “best” evidence and (b) combining results from multiple RCTs will give you an average “effect size”.</p> <p>But RCTs are only the undisputed gold standard for certain kinds of questions. For other questions, a mix of study designs is better. And RCTs should be combined in a meta-analysis only if they are all addressing the same research question in the same way.</p> <p>Here are some reasons why the conclusions of this Cochrane Review are misleading.</p> <h2>It didn’t consider how COVID spreads and how masks work</h2> <p>COVID, along with influenza and many other respiratory diseases, is transmitted primarily <a href="https://theconversation.com/covid-how-the-disease-moves-through-the-air-173490">through the air</a>.</p> <p>Respirators (such as N95s) are designed and regulated to prevent airborne infections by fitting <a href="https://theconversation.com/high-filtration-masks-only-work-when-they-fit-so-we-created-a-new-way-to-test-if-they-do-155987">closely to the face</a> to prevent air leakage and by filtering out 95% or more of potential infectious particles.</p> <p>In contrast, surgical masks are designed to prevent splatter of fluid on the face and are loose-fitting, causing unfiltered air to leak in through the gaps around the mask. The filtration of a surgical mask is not regulated.</p> <p>In other words, respirators are designed for respiratory protection and cloth and surgical masks are not.</p> <p>The review starts with an assumption that masks provide respiratory protection, which is flawed. An understanding of these differences should inform both studies and reviews of those studies.</p> <h2>The studies addressed quite different questions</h2> <p>A common mistake in meta-analysis is to combine apples and oranges. If apples work but oranges don’t, combining all studies in a single average figure may lead to the conclusion that apples do not work.</p> <p>This Cochrane Review combined RCTs where face masks or respirators were worn part of the time (for example, when caring for patients with known COVID or influenza: “occasional” or “targeted” use) with RCTs where they were worn at all times (“continuous use”).</p> <p>Because both SARS-CoV-2 and influenza viruses are airborne, an unmasked person could be infected anywhere in the building and even after an infectious patient has left the room, especially since some people have <a href="https://www.pnas.org/doi/10.1073/pnas.2109229118">no symptoms</a> while contagious.</p> <p>Most RCTs of masks and N95s included in the review have not had a <a href="https://jamanetwork.com/journals/jama/fullarticle/184819">control arm</a> – therefore finding no difference could indicate equal efficacy or equal inefficacy.</p> <p><a href="https://jamanetwork.com/journals/jama/fullarticle/2749214">Studies</a> examining wearing a surgical mask or respirator (such as an N95) only when in contact with sick people or when doing a high-risk procedure (occasional use) have generally shown that, when worn in this way, there is no difference.</p> <p>An RCT comparing occasional versus continuous use of respirators in health care workers <a href="https://www.atsjournals.org/doi/10.1164/rccm.201207-1164OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubme">showed</a> N95 respirators and surgical masks were equally ineffective when only worn occasionally by hospital workers. They had to wear them all the time at work to be protected.</p> <p>We also combined only apples and apples in a <a href="https://onlinelibrary.wiley.com/doi/10.1111/irv.12474">meta-analysis</a> of two RCTs conducted in exactly the same way and measuring the same interventions and outcomes. We found N95 respirators provide significant protection against respiratory infections when surgical masks did not, even against infections assumed to be “droplet spread”.</p> <h2>Most trials addressed only half the question</h2> <p>Face masks and respirators work in two ways: they protect the wearer from becoming infected and they prevent an infected wearer from spreading their germs to other people.</p> <p>Most RCTs in this Cochrane Review looked only at the former scenario, not the latter. In other words, the researchers had asked people to wear masks and then tested to see if those people became infected.</p> <p>A previous <a href="https://pubmed.ncbi.nlm.nih.gov/20092668/">systematic review</a> found face masks worn by sick people during an influenza epidemic reduced the risk of them transmitting the infection to family members or other carers. Preventing an infection in one person also prevents onward transmission to others within a closed setting, which means such RCTs should use a special method called “cluster randomisation” to account for this.</p> <p>Data from a RCT of N95 respirator use by <a href="https://journals.sagepub.com/doi/full/10.1177/0300060516665491?rfr_dat=cr_pub++0pubmed&amp;url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org">health workers</a> showed even their unmasked colleagues were protected. Yet some of the trials included in the review did not use cluster randomisation.</p> <h2>The new paper combined health and community settings</h2> <p>This is another apples-plus-oranges issue. Different settings have widely differing risks of transmission, since airborne particles build up when sick patients are exhaling the virus in <a href="https://theconversation.com/heres-where-and-how-you-are-most-likely-to-catch-covid-new-study-174473">underventilated, crowded settings</a> especially if many infected people are present (such as in a hospital).</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Here’s where (and how) you are most likely to catch COVID – new study <a href="https://t.co/Ro88Shc897">https://t.co/Ro88Shc897</a> <a href="https://t.co/TlFA9EQskF">pic.twitter.com/TlFA9EQskF</a></p> <p>— Jeffrey J Davis (@JeffreyJDavis) <a href="https://twitter.com/JeffreyJDavis/status/1484210379093954564?ref_src=twsrc%5Etfw">January 20, 2022</a></p></blockquote> <p>A genuine protective effect of masks or respirators shown in a RCT in a high-risk setting will be obscured if that trial is combined in a meta-analysis with several other RCTs that were conducted in low-risk settings.</p> <p>A large <a href="https://www.science.org/doi/10.1126/science.abi9069">RCT in the community in Bangladesh</a> found face masks reduced the risk of infection by 11% overall and 35% in people over 60 years. In contrast, in <a href="https://onlinelibrary.wiley.com/doi/10.1111/irv.12474">hospitals</a>, N95 reduce risk by 67% against bacterial infections and 54% against viral infections.</p> <p>Viruses like influenza also vary substantially from year to year – some years there is very little influenza, and if a RCT is conducted during such a year, it will not find enough infections to show a difference. The review failed to account for such seasonal effects.</p> <h2>But did they actually wear the mask?</h2> <p>The authors of the Cochrane Review acknowledged compliance with masking advice was poor in most studies. In the real world, we can’t force people to follow medical advice, so RCTs should be analysed on an “intention to treat” basis.</p> <p>For example, people who are prescribed the active drug but who choose not to take it should not be shifted to the placebo group for the analysis. But if in a study of masking, most people don’t actually wear them, you can’t conclude that masks don’t work when the study shows no difference between the groups. You can only conclude that the mask advice didn’t work in this study.</p> <p>There is a great deal of <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246317">psychological evidence</a> on why people do or don’t choose to comply with advice to mask and how to improve uptake. The science of masking needs to separate the impact of the mask itself from the impact of the advice to mask.</p> <p>Mask-wearing <a href="https://www.ijidonline.com/article/S1201-9712(21)00274-5/fulltext">goes up</a> substantially to over 70% if there is an actual mandate in place.</p> <h2>It didn’t include other types of research</h2> <p>A comprehensive review of the evidence would also include other types of study besides RCTs. For example, a <a href="https://www.sciencedirect.com/science/article/pii/S0140673620311429">large systematic review</a> of 172 various study designs, which included 25,697 patients with SARS-CoV-2, SARS, or MERS, concluded masks were effective in preventing transmission of respiratory viruses.</p> <p>Well-designed <a href="https://www.cdc.gov/mmwr/volumes/71/wr/mm7106e1.htm?s_cid=mm7106e1_w">real-world studies</a> during the pandemic showed any mask reduces the risk of COVID transmission by 50–80%, with the highest protection offered by N95 respirators.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/20095070/">Many lab-based studies</a> have shown respirators are superior to masks at preventing airborne respiratory infections and the <a href="https://thorax.bmj.com/content/75/11/1024.long">incremental superiority</a> from a single to two layered cloth mask to a three-layered surgical mask in blocking respiratory aerosols.</p> <h2>Yes, masks reduce the spread of COVID</h2> <p>There is strong and consistent evidence for the effectiveness of masks and (even more so) respirators in protecting against respiratory infections. Masks are an important protection against serious infections.</p> <p>Current COVID vaccines protect against death and hospitalisation, but do <a href="https://fortune.com/well/2023/01/06/kraken-xbb15-omicron-covid-variant-most-transmissible-yet-could-spawn-more-immune-evasive-variants-study-china-vaccine-monoclonal-antibodies-breakthrough-infection/">not prevent infection</a> well due to waning vaccine immunity and substantial immune escape from new variants.</p> <p>A systematic review is only as good as the rigour it employs in combining similar studies of similar interventions, with similar measurement of outcomes. When very different studies of different interventions are combined, the results are not informative.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/yes-masks-reduce-the-risk-of-spreading-covid-despite-a-review-saying-they-dont-198992" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Body

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Researchers puzzled by results of anti-inflammatory medications for osteoarthritis

<p>Researchers in the US are calling for a re-evaluation of the way some well known painkillers are prescribed after research showed they may actually lead to a worsening of inflammation over time in osteoarthritis-affected knee joints.</p> <p>NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) such as ibuprofen and naproxen are designed to reduce inflammation for the estimated 2.2 million Australians suffering from the sometimes debilitating effects of osteoarthritis.</p> <p>Osteoarthritis is a degenerative condition affecting joints in the body – most commonly hips, knees, ankles, spine and hands – which results from the degradation of cartilage on the ends of bones within the joints. As the cartilage wears away, the bones rub together resulting in swelling, pain and restricted movement.</p> <p>To combat this pain and swelling, NSAIDs are commonly prescribed, however the long-term impact of this type of medication is unclear, including its effect on the progression of the condition.</p> <p>“To date, no curative therapy has been approved to cure or reduce the progression of knee osteoarthritis,” said the study’s lead author, Johanna Luitjens, from the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. “NSAIDs are frequently used to treat pain, but it is still an open discussion of how NSAID use influences outcomes for osteoarthritis patients.</p> <p>Surprisingly the report says: “…the impact of NSAIDs on synovitis, or the inflammation of the membrane lining the joint, has never been analysed using MRI-based structural biomarkers.”</p> <p>The study compared 793 participants with moderate to severe osteoarthritis of the knee who did not use NSAIDs, with 277 patients who received sustained treatment with NSAIDs for more than a year. Each patient underwent Magnetic Resonance Imaging (MRI) scans of the joint, which were then repeated after four years.</p> <p>The researchers were able to assess the images for indications of inflammation and arthritis progression including cartilage thickness and composition.</p> <p>The data showed the group using NSAIDs, had worse joint inflammation and cartilage quality than those not using NSAIDs, at the time of the initial MRI scan. And the follow-up imaging showed the conditions had worsened for the NSAID group.</p> <p>“In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint,” said Luitjens.</p> <p>According to Luitjens, the common practice of prescribing NSAIDs for osteoarthritis should be revisited as there doesn’t appear to be any evidence they have a positive impact on joint inflammation nor do they slow or prevent synovitis or degenerative changes in the joint.</p> <p>There is also a possibility that NSAIDs simply mask the pain. Despite adjusting the study’s model for individual levels of patient physical activity, “patients who have synovitis and are taking pain-relieving medications may be physically more active due to pain relief, which could potentially lead to worsening of synovitis,” said Luitjens.</p> <p>Luitjens hopes future studies will better characterise NSAIDs and their impact on osteoarthritic inflammation. With one in three people over the age of 75 in Australia suffering from osteoarthritis and an estimated one in 10 women and one in 16 men set to develop it in the future, unlocking treatment options for this crippling condition is an imperative.</p> <p><strong>This article originally appeared on <a href="https://cosmosmagazine.com/science/osteoarthritis-puzzled-antiinflammatory/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Clare Kenyon.</strong></p> <p><em>Image: Shutterstock</em></p>

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Victorian man’s anti-Dan Andrews plates deemed “offensive” by government

<p dir="ltr">A Victorian man could lose his personalised number plates referencing Premier Daniel Andrews after the state government’s transport body said they had deemed them to be “offensive” and “inappropriate”.</p> <p dir="ltr">In September, Peter Dunlevie received plates that read, “DANOUT”, from VicRoads and attached them to his 2003 Commodore ahead of the state election on November 23.</p> <p dir="ltr">“Well, I want Andrews gone,” he told <em>7NEWS</em>.</p> <p dir="ltr">“I’m just sick of him.”</p> <p><span id="docs-internal-guid-907adc51-7fff-b3f2-85a0-ade8c73e54ba"></span></p> <p dir="ltr">The plates are accompanied by other anti-Andrews messages, including stickers reading, “Save Victoria” and “SACK ANDREWS”.</p> <p dir="ltr"><img src="https://oversixtydev.blob.core.windows.net/media/2022/11/danout1.jpg" alt="" width="880" height="495" /></p> <p dir="ltr"><em>Peter Dunlevie attached plates reading ‘DANOUT’ to his white Commodore. Image: 7NEWS</em></p> <p dir="ltr">However, VicRoads has since written to the Gippsland man and told him to return the plates, writing that the plates are “negative”, “offensive” and “inappropriate”.</p> <p dir="ltr">“A review of our records has identified that the combination ‘DANOUT’ has specific negative references, and may be considered offensive by the broader community,” the letter read.</p> <p dir="ltr">Dunlevie has questioned VicRoads’ assessment of the plates, telling the news outlet that it’s just “a bit of fun”.</p> <p dir="ltr">“What’s offensive about them?” he said.</p> <p dir="ltr">“This is just an old bloke having a bit of fun.”</p> <p dir="ltr">While VicRoads has the authority to cancel personalised plates, Dunlevie said he felt like the transport authority was “trying to gag me”.</p> <p dir="ltr">Following the letter from VicRoads, the state’s Department of Transport has begun a review into the decision to remove the plates from Dunlevie.</p> <p dir="ltr"><span id="docs-internal-guid-2976ccdd-7fff-1b07-2086-9bc20f7378ca"></span></p> <p dir="ltr"><em>Image: 7NEWS</em></p>

Travel Trouble

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COVID-19 virus-detecting mask can alert of exposure via your smartphone

<p>Move over <a href="https://cosmosmagazine.com/health/covid/rise-of-rapid-antigen-testing/" target="_blank" rel="noreferrer noopener">inaccurate RATs</a>. Get out of my nose and throat PCR swab tests. There’s a new method of COVID-19 detection and it’s wearable.</p> <p>A research team from Tongji University in China, has created a face mask that can detect COVID-19 (as well as other common respiratory viruses such as colds and influenza) and send an alert to your smartphone.</p> <p>The mask is highly sensitive, with the inbuilt sensor able to detect the virus <a href="https://cosmosmagazine.com/health/lets-clear-the-air-on-ventilation-cosmos-weekly-taster/" target="_blank" rel="noreferrer noopener">in the air</a> after only ten minute’s exposure at extremely low concentrations – far less than produced by sneezing, coughing or talking.</p> <p>“Previous research has shown face mask wearing can reduce the risk of spreading and contracting the disease. So, we wanted to create a mask that can detect the presence of virus in the air and alert the wearer,” says Yin Fang, an author of the study and a material scientist at Shanghai Tongji University.</p> <div class="newsletter-box"> <div id="wpcf7-f6-p214217-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> <form class="wpcf7-form mailchimp-ext-0.5.62 spai-bg-prepared init" action="/science/covid-19-detecting-mask-smartphone/#wpcf7-f6-p214217-o1" method="post" novalidate="novalidate" data-status="init"> <p style="display: none !important;"><span class="wpcf7-form-control-wrap referer-page"><input class="wpcf7-form-control wpcf7-text referer-page" name="referer-page" type="hidden" value="https://cosmosmagazine.com/people/" data-value="https://cosmosmagazine.com/people/" aria-invalid="false" /></span></p> <p><!-- Chimpmail extension by Renzo Johnson --></form> </div> </div> <p>The sensor on the mask has tiny synthetic molecules – called ‘aptamers’ – which are able to be tweaked to detect proteins unique to specific pathogens, such as SARS-Cov-2, H5N1 (colloquially known as ‘bird flu’) and H1N1 (‘swine flu’). Once the aptamer detects the virus, the sensor amplifies the signal via a specialised component known as an <a href="https://www.researchgate.net/publication/344400852_Ion-Gated_Transistor_An_Enabler_for_Sensing_and_Computing_Integration" target="_blank" rel="noreferrer noopener">ion-gate transistor</a> (which is highly sensitive and able to detect very low voltage signals) and sends an alert to the user’s phone.</p> <p>“Our mask would work really well in spaces with poor ventilation, such as elevators or enclosed rooms, where the <a href="https://cosmosmagazine.com/health/covid-ventilation-standards/" target="_blank" rel="noreferrer noopener">risk of getting infected is high</a>,” Fang says. The device is also highly customisable and can be swiftly modified to detect new and emerging threats.</p> <p>This is not the first time <a href="https://cosmosmagazine.com/health/smart-masks-to-detect-covid-19/" target="_blank" rel="noreferrer noopener">‘smart masks’ have been created</a> to detect COVID-19, but what sets these devices apart is their sensitivity and ‘tunability’ to different viruses.</p> <p>The team is working on reducing the detection time and increasing the sensitivity of their devices. In the future, they hope the technology could be expanded to further applications and wearables for other conditions such as cancers and heart diseases.</p> <p>“Currently, doctors have been relying heavily on their experiences in diagnosing and treating diseases. But with richer data collected by wearable devices, disease diagnosis and treatment can become more precise,” Fang says.</p> <p><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --></p> <p><img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=214217&amp;title=COVID-19+virus-detecting+mask+can+alert+of+exposure+via+your+smartphone" width="1" height="1" /></p> <p><!-- End of tracking content syndication --></p> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/science/covid-19-detecting-mask-smartphone/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/clare-kenyon" target="_blank" rel="noopener">Clare Kenyon</a>. Clare Kenyon is a science journalist for Cosmos. An ex-high school teacher, she is currently wrangling the death throes of her PhD in astrophysics, has a Masters in astronomy and another in education. Clare also has diplomas in music and criminology and a graduate certificate of leadership and learning.</em></p> <p><em>Image: Getty Images</em></p> </div>

Technology

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National Day of Mourning brings anti-monarchy activists to the streets

<p>While many Australians were mourning the death of Queen Elizabeth on the specially appointed public holiday, anti-monarchy activists took to the streets to celebrate the end of her reign.</p> <p>With protests taking place in Sydney, Melbourne, Brisbane and Adelaide, activists declared "I'm glad the b**** is dead" just hours after Prime Minister Anthony Albanese paid affectionate tribute to the deceased monarch on the country’s National Day of Mourning.</p> <p>Several hundred demonstrators gathered on the steps of Sydney's Town Hall to protest the institution of the royal family and call for an Australian republic, Indigenous sovereignty, a treaty with Aboriginal Australians, and reparations for past wrongs.</p> <p>Under heavy police presence, speakers listed demands and grievances against British monarchs going back to Queen Victoria.</p> <p>Many of the speeches were heavily laced with profanity and declarations such as “f*** the royal family.”</p> <p>One speaker enthusiastically sang, “If you’re happy that she’s dead, clap your hands!”</p> <p>Signs reading “Sovereignty never ceded” and “It’s Aboriginal land” were seen throughout the crowd.</p> <p>Despite the strong anti-monarchy rhetoric, a small group of counter-protestors showed up to show their support for the late Queen and the monarchy.</p> <p>While their counter was peaceful, they were asked to move by police who said they feared inflaming a “tense situation”.</p> <p>Dana Pham, 34, a self-described constitutional monarchist whose parents emigrated as refugees from Vietnam, stood to one side holding a portrait of the late Queen.</p> <p>“I like everyone else want to see the gap closed,” she said.</p> <p>“Obviously there are a lot of issues affecting Aboriginal communities, but … the twisting of history does nobody any favours,” she said.</p> <p><em>Image credits: Getty Images</em></p>

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M*A*S*H, 50 years on: the anti-war sitcom was a product of its time, yet its themes are timeless

<p>MASH, stylised as M*A*S*H, is the story of a rag-tag bunch of medical misfits of the 4077th Mobile Army Surgical Hospital thrown together against the horrors of the Korean war in the 1950s. The series endured for 11 seasons, from September 1972 to the final episode in 1983.</p> <p>Originally it was centred on two army surgeons, the wisecracking but empathetic Benjamin “Hawkeye” Pierce, played by Alan Alda, and the deadpan “Trapper” John McIntyre, played by Wayne Rogers.</p> <p>The show had an ensemble cast and different episodes would often focus on one of the featured characters.</p> <p>There was the meek Corporal “Radar” O'Reilly, cross-dressing Corporal Klinger, the easy-going Lieutenant Colonel Henry Blake and pious Father Mulcahy. The antagonists, conniving Major Frank Burns and Major Margaret “Hot Lips” Houlihan, were foils for Hawkeye and Trapper but occasionally were central characters in some episodes too.</p> <div data-id="17"> </div> <p>Based on the 1970 movie, itself based on a novel, MASH was designed as a “black comedy” set during the Korean War.</p> <p>It was really a thinly veiled critique of the war in Vietnam raging at the time.</p> <p>The creators of the show knew they wouldn’t get away with making a Vietnam war comedy. Uncensored news broadcasts showing the viciousness of Vietnam were transmitted straight to the American public who were, by now, growing jaded of the increasingly brutal war.</p> <p>Setting the series 20 years earlier allowed the creators to mask their criticisms behind a historical perspective – but most viewers realised the true context.</p> <h2>An anti-war sitcom</h2> <p>What started as a criticism of the Vietnam war soon evolved into one for all wars.</p> <p>In many episodes, audiences would be reminded of the horrors of lives lost in the fighting on the line, and the angst and trauma faced by those behind the line.</p> <p>It didn’t matter which war this was, MASH was saying all wars are the same, full of shattered lives.</p> <p>Cloaking this message in comedy was the way the creators were able to make it palatable to a wide audience.</p> <p>The early seasons have a distinctive sitcom feel to them, mostly as a result of the series co-creators, Larry Gelbart and Gene Reynolds, who were from a comedy background.</p> <p>When both creatives left by the end of season five the show took a more dramatic turn.</p> <p>In particular, Alda became more involved in the writing and took it into a more dramatic direction, toning down the comedic elements. This was also reflected in the change of many of the secondary characters.</p> <p>The philandering, practical joker Trapper was replaced by the moral and professional BJ Hunnicutt, the snivelling Frank Burns by the pretentious Charles Winchester, the laconic Henry Blake with the officious Sherman Potter, and the complete absence of Radar after season eight. The voice of the series took on a noticeably Hawkeye focus.</p> <p>As the Vietnam war ended in 1975, the tone of the show also changed. It became less political and focused more on the dilemmas of the individual characters. The laugh track was toned down. But this did not make the show any less popular.</p> <p>Audiences responded strongly to the anarchic anti-authoritarianism of Hawkeye and Trapper/BJ.</p> <p>Almost all the characters are anti-war, reflecting the growing antagonism the American public was feeling towards the Vietnam war and war fatigue in general, post-Vietnam.</p> <p>Even Frank and Hot Lips, the most patriotic characters, sometimes questioned if the war was worth all the suffering and death. And the series reminded people the humour used was not meant to disrespect those fighting but as a coping mechanism of the trauma by those involved.</p> <h2>A timeless classic</h2> <p>That’s not to say there aren’t issues with the show when looked at with modern sensibilities.</p> <p>Contemporary audiences would find problems with some of the representations of characters and issues addressed in the series. Corporal Klinger would today be seen as contentious. His penchant for dressing in women’s clothes was not because he was trans or interested in drag, but because he was trying to get a “Section 8”, or mental health, discharge.</p> <p>Many of the female characters were also relegated to little more than two-dimensional romantic interests or background characters.</p> <p>The only woman who starred with a significant recurring role was “Hot Lips” Houlihan but, as the nickname implies, she was often the butt of sexualised humour.</p> <p>This has not stopped the show maintaining its popularity in the continual re-runs it gets on cable and streaming services.</p> <p>MASH was a product of its time, yet its themes on the absurdity of war are universal. It became more than a TV show: a shared cathartic experience for war-weary audiences.</p> <p>At its heart is the eclectic mix of dysfunctional characters who use humour to laugh in the face of adversity. This is what makes MASH a timeless classic.</p> <p><strong>This article originally appeared on <a href="https://theconversation.com/m-a-s-h-50-years-on-the-anti-war-sitcom-was-a-product-of-its-time-yet-its-themes-are-timeless-190422" target="_blank" rel="noopener">The Conversation</a>.</strong></p> <p><em>Image: YouTube</em></p>

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